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Lupus anticoagulant. Implications for obstetric anaesthetists
A M Malinow1, W J Rickford, B L Mokriski
1Department of Anesthesiology, University of Maryland Medical System, Baltimore 21201.
Anaesthesia
|December 1, 1987
Summary
Lupus anticoagulant, an auto-antibody found in systemic lupus erythematosus patients, increases thrombosis risk and pregnancy complications. Anti-platelet therapy improves perinatal survival but complicates anesthesia choices.
Area of Science:
- Immunology
- Hematology
- Obstetrics
Background:
- Circulating lupus anticoagulant (LA) affects 5-37% of systemic lupus erythematosus (SLE) patients.
- LA is linked to systemic intravascular thrombosis and placental vascular issues.
- Pregnancies with LA have a low success rate (less than 1 in 6).