Bone regeneration in diabetic patients. A systematic review

Area of Science:

• Dental Implantology
• Regenerative Medicine
• Endocrinology

Background:

• Oral bone regeneration techniques (OBRT) are crucial for successful dental implant treatments.
• Assessing OBRT clinical outcomes in diabetic versus non-diabetic patients is important.
• The scientific evidence level for OBRT in diabetic patients requires evaluation.

Purpose of the Study:

• To compare clinical outcomes of oral bone regeneration techniques (OBRT) between diabetic and non-diabetic patients.
• To evaluate the scientific evidence supporting OBRT in diabetic individuals.
• To determine the strength of recommendation for OBRT in diabetic patients.

Main Methods:

• A systematic review of PubMed, Scopus, and Cochrane databases was performed.
• Searched for studies on "Diabetes Mellitus" and various bone regeneration techniques published within the last 10 years.
• Included human studies with at least 10 patients, comparing OBRT in diabetic and non-diabetic groups, stratified by SORT criteria.

Main Results:

• The systematic review identified 7 relevant studies after screening 131 articles.
• The included studies comprised 2 controlled clinical trials, 1 cohort study, and 4 case series.
• A low grade of scientific evidence was found regarding OBRT in diabetic patients.

Conclusions:

• A low grade of evidence exists for oral bone regeneration techniques (OBRT) in diabetic patients.
• The heterogeneity of diabetic patient types and applied techniques leads to a Type C recommendation.
• Further research is needed to establish clear guidelines for OBRT in diabetic individuals.