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Related Experiment Videos

Segregation distortion in Rh polymorphism.

J Rajanikumari1, C R Srikumari

  • 1Department of Human Genetics and Physical Anthropology, Andhra University, Waltair (A.P.), India.

Anthropologischer Anzeiger; Bericht Uber Die Biologisch-Anthropologische Literatur
|December 1, 1987
PubMed
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Rh system segregation distortion was observed in South Indian populations. Rh-negative children were fewer from Rh-positive mothers, indicating a reduction in the

Area of Science:

  • Human Genetics
  • Population Genetics
  • Immunogenetics

Background:

  • The Rh blood group system is crucial in transfusion medicine and pregnancy.
  • Understanding genetic transmission patterns, like segregation, is key to population genetics.
  • Previous studies have suggested potential genetic influences on Rh allele transmission.

Purpose of the Study:

  • To investigate segregation distortion in the Rh system.
  • To analyze the transmission patterns of Rh D-d alleles in mother-child pairs and families.
  • To identify factors influencing Rh allele frequencies in a South Indian population.

Main Methods:

  • Genotyping of D-d alleles of the Rh system in 1018 mother-infant pairs and 216 families (692 children).
  • Segregation analysis using the T matrix method of ITO matrices.

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  • Statistical analysis assuming Hardy-Weinberg equilibrium.

    • Main Results:

    • Significant reduction in Rh-negative children born to Rh-positive mothers.
    • Less significant increase in Rh-positive children born to Rh-negative mothers.
    • Observed distortion leads to a decrease in the 'd' allele frequency from mothers to children.

    Conclusions:

    • Segregation distortion in the Rh system is evident in the studied South Indian population.
    • Standard explanations like Rh antigenic specificities or reproductive compensation do not account for the observed distortion.
    • Selective forces, potentially linked to Rh compatibility, may be operating to maintain Rh allele polymorphism.