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Segregation distortion in Rh polymorphism.

J Rajanikumari¹, C R Srikumari

¹Department of Human Genetics and Physical Anthropology, Andhra University, Waltair (A.P.), India.

Anthropologischer Anzeiger; Bericht Uber Die Biologisch-Anthropologische Literatur

|December 1, 1987

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Rh system segregation distortion was observed in South Indian populations. Rh-negative children were fewer from Rh-positive mothers, indicating a reduction in the

Area of Science:

Human Genetics
Population Genetics
Immunogenetics

Background:

The Rh blood group system is crucial in transfusion medicine and pregnancy.
Understanding genetic transmission patterns, like segregation, is key to population genetics.
Previous studies have suggested potential genetic influences on Rh allele transmission.

Purpose of the Study:

To investigate segregation distortion in the Rh system.
To analyze the transmission patterns of Rh D-d alleles in mother-child pairs and families.
To identify factors influencing Rh allele frequencies in a South Indian population.

Main Methods:

Genotyping of D-d alleles of the Rh system in 1018 mother-infant pairs and 216 families (692 children).
Segregation analysis using the T matrix method of ITO matrices.

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Statistical analysis assuming Hardy-Weinberg equilibrium.

Main Results:

Significant reduction in Rh-negative children born to Rh-positive mothers.
Less significant increase in Rh-positive children born to Rh-negative mothers.
Observed distortion leads to a decrease in the 'd' allele frequency from mothers to children.

Conclusions:

Segregation distortion in the Rh system is evident in the studied South Indian population.
Standard explanations like Rh antigenic specificities or reproductive compensation do not account for the observed distortion.
Selective forces, potentially linked to Rh compatibility, may be operating to maintain Rh allele polymorphism.