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Updated: Jan 22, 2026

Isolation and Culture of Human Adipose-Derived Stem Cells With an Innovative Xenogeneic-Free Method for Human Therapy
Published on: February 3, 2023
Adipose-derived cellular and cell-derived regenerative therapies in dermatology and aesthetic rejuvenation
Annie Suh1, Anthony Pham1, Mikel Jean Cress1
1Department of Transplantation Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Jacksonville, FL, 32224, United States.
Abstract:
Cellular and cell-derived components of adipose-derived tissue for the purposes of dermatologic and aesthetic rejuvenation applications have become increasingly studied and integrated into clinical practice. These components include micro-fragmented fat (nanofat), the stromal vascular fraction (SVF), adipose-derived mesenchymal stem cells (ASC), and extracellular vesicles (EVs), which have all shown capability to repair, regenerate, and rejuvenate surrounding tissue. Various aesthetic applications including hair growth, scar reduction, skin ischemia-reperfusion recovery, and facial rejuvenation are reviewed. In particular, results from preclinical and clinical studies are discussed, with a focus on clarification of nomenclature.
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