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Platelet-reactive sites in collagen. Collagens I and III possess different aggregatory sites
L F Morton1, C M Fitzsimmons, J Rauterberg
1Strangeways Research Laboratory, Cambridge, U.K.
The Biochemical Journal
|December 1, 1987
Abstract:
Collagen type III possesses a highly reactive platelet-aggregatory site at a locus which in type I is essentially inactive whilst the latter collagen possesses reactive sites absent in type III. It is proposed that platelet aggregation by collagen involves the sequence GK[or R]PG(EY)GPK[or R]G(EY) or, less favourably, GPK[or R]G(EY)G(XY)GK[or R]PG(EY), one basic residue acting in combination with the second in an adjacent alpha-chain.