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Updated: Jan 22, 2026
08:45
Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
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Ironing out Macrophage Immunometabolism
Stefania Recalcati1, Elena Gammella2, Gaetano Cairo3
1Department of Biomedical Sciences for Health, University of Milan, 20133 Milan, Italy. stefania.recalcati@unimi.it.
Pharmaceuticals (Basel, Switzerland)
|June 29, 2019
Summary
Metabolic reprogramming is crucial for macrophage activation and function. Iron metabolism within macrophages influences their plasticity and impacts immune responses and cell microenvironments.
Area of Science:
- Immunometabolism
- Cellular Metabolism
- Macrophage Biology
Background:
- Metabolic reprogramming is increasingly recognized as central to macrophage activation.
- Intracellular metabolic pathways regulate immune responses and effector functions of immune cells.
- Iron metabolism is a key factor in macrophage plasticity and function.
Purpose of the Study:
- To review the role of iron metabolism in macrophage activation and plasticity.
- To discuss how macrophage iron availability affects immune responses.
- To explore the connection between macrophage iron and immunometabolism.
Main Methods:
- Literature review of studies on macrophage metabolism and iron.
- Analysis of gene expression related to iron metabolism in macrophages.
- Discussion of experimental evidence linking iron to macrophage function.
Main Results:
- Macrophage metabolic reprogramming is essential for their activation and specialized functions.
- Iron metabolism significantly influences macrophage plasticity and effector functions.
- Changes in macrophage iron metabolism affect iron availability for other cells in the microenvironment.
Conclusions:
- Macrophage iron metabolism is a critical component of immunometabolism.
- Understanding macrophage iron dynamics is key to modulating immune responses.
- Iron availability controlled by macrophages impacts both the cells themselves and their surrounding microenvironment.
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