Closer to the Truth on National Fistula Prevalence After Unilateral Complete Cleft Lip and Palate Repair? The Cleft

Arthur S Yang1, Bruce M Richard2, Andrew K Wills3,4

  • 1Department of Plastic Surgery, Waikato Hospital, Hamilton, New Zealand.

Insights

The prevalence of non-perialveolar palatal fistulas in children with unilateral cleft lip and palate (UCLP) up to age 5 in the UK is 31.3%. Further research is needed to link fistula occurrence to specific surgical techniques or protocols.

Area of Science:

  • Craniofacial Surgery
  • Pediatric Surgery
  • Oral and Maxillofacial Surgery

Background:

  • Non-perialveolar palatal fistulas are a potential complication following surgical repair of unilateral cleft lip and palate (UCLP).
  • Understanding the prevalence and factors associated with fistula formation is crucial for improving surgical outcomes in UCLP patients.

Purpose of the Study:

  • To determine the prevalence of non-perialveolar palatal fistulas up to age 5 in UCLP patients in the UK.
  • To examine the association between palatoplasty techniques and fistula occurrence.
  • To describe the frequency and success rates of fistula repairs.

Main Methods:

  • A cross-sectional study involving 268 children with non-syndromic UCLP, recruited through the Cleft Care UK nationwide study.
  • Data collected from all 11 centralized regional cleft centers in the United Kingdom.
  • Prevalence of non-perialveolar palatal fistulas up to age 5 was the main outcome measure.

Main Results:

  • Fistulas were identified in 72 children (31.3%), with no significant association found with palate repair sequences.
  • Twenty-four fistulas were repaired by age 5, and 10 out of 12 (83.3%) had documented successful repairs.
  • The observed prevalence of fistulas was higher than previously reported in the literature.

Conclusions:

  • The prevalence of non-perialveolar fistulas following primary palatoplasty for UCLP in the UK is substantial and warrants attention.
  • Findings should be incorporated into preoperative discussions with families regarding potential surgical complications.
  • Prospective data collection is essential to establish associations between fistulas and specific surgical factors.
Abstract

Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.6K
National Nursing Organizations I01:26

National Nursing Organizations I

Nursing organizations assume a significant role in consistently developing the nursing profession through education, research studies, establishing practice standards, and reforming health policies. Typically, nursing organizations operate at the regional, national, and international levels. For example, the International Council of Nurses (ICN) represents more than 28 million nurses worldwide. In contrast, the American Nurses Association (ANA) is a membership organization representing nurses...
3.0K
National Nursing Organizations II01:30

National Nursing Organizations II

Nursing organizations play a vital role in representing nurses working in specialized clinical settings, such as the American Association of Critical-Care Nurses (AACN).
The AACN emphasizes a healthy work environment through six standards to achieve an optimal patient outcome. The standards are appropriate staffing, meaningful recognition, collaboration, authentic leadership, effective communication, and decision-making. In addition, AACN provides certification programs, webinars, journals, and...
2.0K
Mismatch Repair01:36

Mismatch Repair

Overview
43.5K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
40.6K
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
33.5K