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sRAGE plays a role as a protective factor in the development of PCOS by inhibiting inflammation
Bi-Jun Wang1,2, Li Qian1, Jing Li1
1Reproductive Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Abstract:
This study determined the effect of exogenous soluble receptor for advanced glycation end products (sRAGE) on the pro-inflammatory activities that occur during polycystic ovary syndrome (PCOS) in human follicular cells and explored a potential mechanism for preventing the development of inflammation. Follicular fluid was allocated into one of three treatment groups (0, 0.6, and 1.2 μg mL-1 of sRAGE). Collectively, these results indicate that exogenous sRAGE supplementation alleviates inflammation in ovarian follicular granulosa cells by regulating p-ERK and AP-1 signaling.
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