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Morphine Use in Renal Failure: A Case Report of Single-Dose Morphine Toxicity in a Patient Requiring Peritoneal

Nicole A Slater1, Anthony M Todd2, Marirose C Trimmier2

  • 1Department of Pharmacy Practice, Harrison School of Pharmacy, 1383Auburn University, AL, USA.

Journal of Pharmacy Practice
|June 29, 2019
PubMed
Abstract

Insights

Morphine toxicity occurred in a patient due to its metabolite, morphine-6-glucuronide, accumulating during peritoneal dialysis. This highlights the risk of using morphine in patients with renal impairment undergoing dialysis.

Area of Science:

  • Pharmacology
  • Nephrology
  • Toxicology

Background:

  • Opioid analgesics are commonly used for pain management.
  • Renal impairment can affect drug metabolism and excretion.
  • Peritoneal dialysis may not effectively clear certain drug metabolites.
Keywords:
M6Ghospicemorphinemorphine toxicityperitoneal dialysisrenal clearance

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