Related Experiment Video
Updated: Jan 22, 2026
06:26
Analysis of Side Population in Solid Tumor Cell Lines
Published on: February 23, 2021
4.8K
Prognostic value of ZEB-1 in solid tumors: a meta-analysis
Borong Chen1, Baisheng Chen2, Zhipeng Zhu1
1Department of Gastrointestinal Surgery, Xiamen Cancer Hospital of The First Affiliated Hospital of Xiamen University, 55 Zhen Hai Road, Si Ming District, Xiamen, 361003, Fujian Province, China.
BMC Cancer
|June 29, 2019
Summary
High expression of Zinc-finger E-box binding homeobox 1 (ZEB-1) is linked to worse overall survival in solid tumors. This meta-analysis suggests ZEB-1 is a potential prognostic biomarker and therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Research
Background:
- Zinc-finger E-box binding homeobox 1 (ZEB-1) is implicated in epithelial-to-mesenchymal transition and tumor progression.
- Previous studies on ZEB-1 as a cancer prognostic biomarker have yielded inconclusive results.
- The prognostic significance of ZEB-1 in human solid tumors requires further investigation.
Purpose of the Study:
- To conduct a meta-analysis evaluating the prognostic value of ZEB-1 in patients with solid tumors.
- To determine if ZEB-1 expression levels correlate with overall survival (OS) in cancer patients.
Main Methods:
- A meta-analysis of 13 studies involving 1616 patients, with data searched from Web of Science, PubMed, and EBSCO up to September 2018.
- Pooled hazard ratios (HR) and 95% confidence intervals (CI) for OS were analyzed using random or fixed effects models.
- Univariate, multivariate, subgroup, heterogeneity, and publication bias analyses were performed to ensure reliability.
Main Results:
- Elevated ZEB-1 expression was significantly associated with worse OS in solid tumor patients.
- Univariate analysis showed a pooled HR for OS of 1.66 (95% CI: 1.45-1.90, P < 0.01).
- Multivariate analysis revealed a pooled HR for OS of 2.28 (95% CI: 1.58-3.30, P < 0.01), with no significant publication bias detected.
Conclusions:
- High ZEB-1 expression correlates with poorer overall survival in human solid tumors.
- ZEB-1 demonstrates potential as a prognostic biomarker for predicting cancer outcomes.
- ZEB-1 may represent a novel therapeutic target for human solid tumors.
Related Concept Videos
02:37Metallic Solids
20.5K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.5K
02:22Structures of Solids
17.5K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.5K
02:18Network Covalent Solids
16.1K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.1K
01:09Directing Effect of Substituents: meta-Directing Groups
5.8K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
5.8K
02:54Molecular and Ionic Solids
20.0K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.0K
02:26Molecular Comparison of Gases, Liquids, and Solids
54.2K
Particles in a solid are tightly packed together (fixed shape) and often arranged in a regular pattern; in a liquid, they are close together with no regular arrangement (no fixed shape); in a gas, they are far apart with no regular arrangement (no fixed shape). Particles in a solid vibrate about fixed positions (cannot flow) and do not generally move in relation to one another; in a liquid, they move past each other (can flow) but remain in essentially constant contact; in a gas, they move...
54.2K