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Updated: Jan 22, 2026

Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue
Batika M J Rana1, Eric Jou1, Jillian L Barlow1
1Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
None:
Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal cells (WAT-MSCs) can act as a reservoir for IL-33, especially after cell stress, but also provide additional signals for sustaining ILC2. Indeed, we demonstrate that WAT-MSCs also support ICAM-1-mediated proliferation and activation of LFA-1-expressing ILC2s. Consequently, ILC2-derived IL-4 and IL-13 feed back to induce eotaxin secretion from WAT-MSCs, supporting eosinophil recruitment. Thus, MSCs provide a niche for multifaceted dialogue with ILC2 to sustain a type-2 immune environment in WAT.
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