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Complete Genome Sequences of Staphylococcus epidermidis Myophages Quidividi, Terranova, and Twillingate
Miranda E Freeman1, Sarah E Kenny1, Amanda Lanier1
1Center for Phage Technology, Texas A&M University, College Station, Texas, USA.
Microbiology Resource Announcements
|June 29, 2019
Abstract:
Staphylococcus epidermidis is an opportunistic pathogen that commonly colonizes human skin and mucous membranes. We report here the complete genome sequences of three S. epidermidis phages, Quidividi, Terranova, and Twillingate, which are members of the Twort-like group of large myophages infecting Gram-positive hosts.
Insights
Researchers sequenced three Staphylococcus epidermidis phages: Quidividi, Terranova, and Twillingate. These large myophages infect Gram-positive bacteria and are part of the Twort-like group, offering insights into phage biology.
Area of Science:
- Microbiology
- Genomics
- Virology
Background:
- Staphylococcus epidermidis is a common skin colonizer and opportunistic pathogen.
- Bacteriophages (phages) are viruses that infect bacteria and can be used for phage therapy.
- Twort-like phages are a group of large myophages known to infect Gram-positive bacteria.
Purpose of the Study:
- To report the complete genome sequences of three novel Staphylococcus epidermidis phages.
- To characterize these phages as members of the Twort-like group.
- To provide genomic resources for understanding S. epidermidis-phage interactions.
Main Methods:
- Whole-genome sequencing of Quidividi, Terranova, and Twillingate phages.
- Bioinformatic analysis of the obtained genome sequences.
- Phylogenetic analysis to determine phage classification.
Main Results:
- The complete genome sequences for phages Quidividi, Terranova, and Twillingate were determined.
- These three phages were confirmed as members of the Twort-like group of large myophages.
- Genomic data provides a foundation for further studies on these S. epidermidis phages.
Conclusions:
- The genomic characterization of Quidividi, Terranova, and Twillingate advances our understanding of Twort-like phages.
- These phage genomes represent valuable resources for potential applications in combating Staphylococcus epidermidis infections.
- Further research can explore the biological and therapeutic potential of these sequenced phages.
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