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Related Concept Videos

Histone Modification02:32

Histone Modification

16.0K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

Histone Modification

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Histone Variants at the Centromere02:30

Histone Variants at the Centromere

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Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Regulation of Stroke Volume01:27

Regulation of Stroke Volume

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
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Co-activators and Co-repressors02:04

Co-activators and Co-repressors

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Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
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Cardiac Output and Stroke Volume01:11

Cardiac Output and Stroke Volume

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Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac...
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Updated: Jan 22, 2026

Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay
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Histone deacetylases in stroke.

Mei-Han Kao1, Teng-Nan Lin2

  • 1Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan.

The Chinese Journal of Physiology
|June 29, 2019
PubMed
Summary
This summary is machine-generated.

Epigenetics offers new hope for stroke treatment by targeting multiple injury pathways simultaneously. This review explores histone deacetylases as promising therapeutic targets for ischemic brain injury.

Keywords:
Acetylationcerebral ischemiaepigenetic regulationhistone acetyl transferases

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Stroke is a leading cause of death and disability globally.
  • Existing neuroprotective agents have shown limited success in clinical trials.
  • Effective stroke treatment likely requires targeting multiple pathophysiological cascades.

Purpose of the Study:

  • To provide a comprehensive overview of recent advances in stroke epigenetics.
  • To highlight the potential of epigenetic modifications as therapeutic targets.
  • To focus on the roles of histone deacetylases in ischemic brain injury.

Main Methods:

  • Literature review of epigenetic mechanisms in stroke.
  • Analysis of physiological and pathological functions of histone deacetylases.
  • Exploration of transcriptional regulation in ischemic disease.

Main Results:

  • Epigenetic modifications influence key pathways in ischemic disease development.
  • Epigenetic molecules can act on multiple levels of brain injury simultaneously.
  • Deoxyribonucleic acid methylation and histone acetylation are key epigenetic modifications.

Conclusions:

  • Epigenetic strategies, particularly targeting histone deacetylases, show promise for stroke therapy.
  • Modulating epigenetic mechanisms offers a potential 'cocktail therapy' approach.
  • Further research into stroke epigenetics could lead to effective clinical treatments.