Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Signal Transduction: Overview01:26

Signal Transduction: Overview

11.4K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
11.4K
Protein Kinases and Phosphatases02:54

Protein Kinases and Phosphatases

15.0K
Proteins undergo chemical modifications that trigger changes in the charge, structure, and conformation of the proteins. Phosphorylation, acetylation, glycosylation, nitrosylation, ubiquitination, lipidation, methylation, and proteolysis are various protein modifications that regulate protein activity. Such modifications are usually enzyme-driven.
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
15.0K
Elements and Compounds01:27

Elements and Compounds

103.3K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
103.3K
Periodic Classification of the Elements04:00

Periodic Classification of the Elements

58.8K
The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
58.8K
Classification of Elements and Compounds02:54

Classification of Elements and Compounds

72.9K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond. Elements are classified as atomic or molecular based on the nature of their basic units.
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
72.9K
Transduction01:16

Transduction

1.4K
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicted protein-protein interactions between sugar beet root maggot trypsins and sugar beet Kunitz trypsin inhibitors using deep learning.

Data in brief·2026
Same author

Navigating the diagnostic 'gray zone': prospective evaluation of an integrated MRI-Biomarker model for renal allograft triage.

Annals of medicine·2026
Same author

Precise zonal diagnosis: multi-b-value DWI model reveals differential predictors of clinically significant prostate cancer in peripheral and transition zones.

Insights into imaging·2026
Same author

Application of integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) in upper abdomen.

Magnetic resonance imaging·2026
Same author

The Rash That Didn't Blanch: A Case Report of Adult-Onset IgA Vasculitis with Underlying Cirrhosis and IgA Nephropathy.

Journal of education & teaching in emergency medicine·2026
Same author

Deep learning analysis of soybean cyst nematode effectors to proven soybean resistance genes and homolog identification in the sugar beet-sugar beet root maggot plant pathosystem.

Data in brief·2026

Related Experiment Video

Updated: Jan 22, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

8.3K

MAPKDB: A MAP kinase database for signal transduction element identification.

Hamdan Ali Alshehri1, Nadim W Alkharouf1, Omar Darwish2

  • 1Department of Computer and Information Sciences, Towson University, Towson, MD 21252, USA.

Bioinformation
|June 29, 2019
PubMed
Summary
This summary is machine-generated.

Nine soybean Mitogen Activated Protein Kinase (MAPK) genes play a defense role against the parasitic nematode Heterodera glycines. A new database, MAPKDB, aids research on these defense MAPKs in soybean.

Keywords:
MAP kinaseMAPKDBdatabase

More Related Videos

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

7.8K
Identification of Kinase-substrate Pairs Using High Throughput Screening
11:13

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

8.6K

Related Experiment Videos

Last Updated: Jan 22, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

8.3K
An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

7.8K
Identification of Kinase-substrate Pairs Using High Throughput Screening
11:13

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

8.6K

Area of Science:

  • Plant molecular biology
  • Signal transduction pathways
  • Genomics and bioinformatics

Background:

  • Mitogen Activated Protein Kinase (MAPK) cascades are crucial for eukaryotic cellular processes, including defense against pathogens.
  • Soybean (Glycine max) possesses 32 MAPKs, with potential roles in plant defense mechanisms.
  • Plant-parasitic nematodes, such as Heterodera glycines, pose significant threats to soybean crops.

Purpose of the Study:

  • To functionally characterize soybean MAPKs involved in defense against the nematode Heterodera glycines.
  • To develop a comprehensive database (MAPKDB) for managing and analyzing soybean MAPK sequence data related to defense.
  • To facilitate research on gene expression and differential regulation of defense MAPKs.

Main Methods:

  • Functional examination of 32 Glycine max MAPKs to identify defense-related genes.
  • Development of the Mitogen Activated Protein Kinase database (MAPKDB) for sequence data management.
  • Incorporation of sequence alignment data for 20 samples (18 experimental + 2 controls) and differential gene expression analysis.

Main Results:

  • Nine out of 32 soybean MAPKs were identified as having a defense function against Heterodera glycines.
  • The MAPKDB provides access to annotations and sequence data for specific defense MAPKs (MPK2, MPK3, MPK4, MPK5, MPK6, MPK13, MPK16, MPK20) in transgenic soybean lines.
  • The database includes data analysis tools for detecting differential gene expression in overexpression (OE) and RNA interference (RNAi) soybean lines.

Conclusions:

  • Specific soybean MAPKs are integral to the plant's defense response against nematode attack.
  • The MAPKDB serves as a valuable resource for researchers studying soybean MAPK functions and defense mechanisms.
  • The developed database supports the investigation of gene regulation and expression patterns in response to biotic stress.