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Time to Target Stroke: Examining the Circadian System in Stroke
Jeremy J Stubblefield1, James D Lechleiter1
1UT Health San Antonio, Department of Cell System & Anatomy, South Texas Research Facility, San Antonio, TX.
The Yale Journal of Biology and Medicine
|June 29, 2019
Summary
Stroke onset links to circadian rhythms, suggesting new chronotherapy treatments targeting astrocytes could improve outcomes for this leading cause of death and disability.
Area of Science:
- Neuroscience
- Chronobiology
- Stroke Research
Background:
- Stroke is a leading cause of death and disability, with limited treatment options.
- Current treatments focus on clot disruption, but new targets are needed to protect neural tissue.
- Stroke incidence peaks in the morning, suggesting a role for the circadian system.
Purpose of the Study:
- To explore the connection between the astrocyte circadian clock and stroke.
- To investigate how astrocytes respond to ischemic injury.
- To identify potential new therapeutic strategies for stroke treatment.
Main Methods:
- Review of existing literature on astrocyte biology, circadian rhythms, and stroke.
- Analysis of molecular responses to ischemia in astrocytes.
- Exploration of the potential for chronotherapy in stroke management.
Main Results:
- Astrocyte circadian clocks are linked to the molecular response to stroke.
- Circadian regulation influences ischemic damage and recovery.
- Astrocyte function during specific times of day impacts stroke outcomes.
Conclusions:
- Astrocyte circadian clocks represent a novel therapeutic target for stroke.
- Chronotherapy, leveraging astrocyte circadian function, shows promise for stroke treatment.
- Further research into astrocyte biology could lead to improved stroke interventions.
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