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Updated: Jan 22, 2026

Environmentally Induced Heritable Changes in Flax
Published on: January 26, 2011
A case of DAPSONE INDUCED METHEMOGLOBINEMIA
Najia Mahmood1, Mutti Ullah Khan2, Ihtisham U L Haq2
11FCPS Medicine, Holy Family Hospital, Rawalpindi Medical University and Allied Hospitals, Rawalpindi, Pakistan.
Abstract:
Methemoglobinemia (MetHb) being a rare cause of cyanosis is generally not considered in its differential diagnosis. Methemoglobinemia is an abnormal Hb produced physiologically by auto-oxidation. If this process of auto oxidation is impaired either due to genetic defect or due to exogenous drugs/ toxins, its level starts rising. Once it is > 3%, tissue hypoxia ensues. Here is a case of dapsone induced MetHb and is reported in a young girl with central cyanosis, and was treated successfully with methylene blue. Methemoglobinemia should be considered in differential diagnoses of cyanosed patient with normal ABGs, PaO2 and cardio-respiratory status. If left untreated, the disease can be fatal.
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