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Updated: Jan 22, 2026
Acute Myocardial Infarction in Rats
Published on: February 16, 2011
New-onset Atrial Fibrillation in Patients Presenting with Acute Myocardial Infarction
Zafar Iqbal1, Muhammad Naeem Mengal2, Abida Badini3
1Interventional Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.
Insights
New-onset atrial fibrillation (AF) complicates 12.5% of acute myocardial infarction (AMI) cases. This study found hypertension to be a significant risk factor for developing AF in AMI patients.
Area of Science:
- Cardiology
- Internal Medicine
- Epidemiology
Background:
- Atrial fibrillation (AF) is a known complication of acute myocardial infarction (AMI), often associated with poor prognosis and increased in-hospital cardiac events and mortality.
- Quantifying the incidence and associated factors of AF in AMI patients is crucial for understanding its impact on patient outcomes.
Purpose of the Study:
- To determine the frequency of new-onset atrial fibrillation (AF) in patients presenting with acute myocardial infarction (AMI).
- To identify factors associated with the occurrence of new-onset AF in AMI patients.
Main Methods:
- An observational study was conducted on 216 patients admitted with AMI and no prior history of AF.
- Patients underwent standard clinical assessment and laboratory investigations.
- New-onset AF was identified through electrocardiographic assessment during admission or hospitalization.
Main Results:
- The study included 216 patients (54.2% male, mean age 50.76 ± 6.00 years).
- Prevalence of diabetes, hypertension, and smoking was 64.8%, 75.9%, and 28.2%, respectively.
- New-onset AF was detected in 12.5% of AMI patients, with a significant association found with hypertension (p<0.05).
Conclusions:
- New-onset atrial fibrillation occurs in 12.5% of patients with acute myocardial infarction.
- Hypertension is a significant risk factor associated with new-onset AF in the context of AMI.
- The findings highlight AF as a notable complication of AMI, particularly in hypertensive individuals.
Abstract:
Background Atrial fibrillation (AF) can be seen secondary to the complications after acute myocardial infarction (AMI), but it has a poor prognosis when occurs independently. These patients are prone to an increased risk of all in-hospital major cardiac complications and also at an increased risk of mortality. Therefore, it is important to quantify the burden of this aggravating complication in an otherwise lethal manifestation of acute coronary syndrome. The aim of this study was to find the frequency of AF in patients presenting with AMI and the factors associated with it. Methods We conducted this observational study on 216 patients who presented with AMI at the largest cardiac center of Karachi, Pakistan from July 2014 to January 2015 with AMI without a past history of AF. Patients underwent routine clinical assessment and laboratory investigations. Atrial fibrillation, detected on electrocardiographic assessment at the time of admission or during hospital stay without a prior history of persistent atrial flutter or paroxysmal atrial fibrillation, was classified as new-onset atrial fibrillation (AF). Results We selected a total of 216 patients, 117 (54.2%) male and mean age of 50.76 ± 6.00 years. Diabetes was found in 140 (64.8%), 164 (75.9%) were hypertensive, and 61 (28.2%) patients were smokers. ST-segment elevation myocardial infarction (STEMI) was diagnosed in 97 (44.9%) patients. The new onset of atrial fibrillation was found in 27 (12.5%) of the patients with AMI. Univariate analysis revealed a statistically significant association of new-onset AF with hypertension. Conclusion The new onset of atrial fibrillation was found in 12.5% of the patients presented with acute myocardial infarction. It is a significant complication in term of its frequency in AMI and it is more common in hypertensive patients.
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