Related Experiment Video
Updated: Jan 22, 2026
06:45
Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
16.0K
Recurrence Risk after First Symptomatic Distal versus Proximal Deep Vein Thrombosis According to Baseline Risk
Luca Valerio1, Chiara Ambaglio2, Marisa Barone3
1Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University-Mainz, Mainz, Germany.
Summary
The location of deep vein thrombosis (DVT) matters for recurrence risk. Distal DVT is favorable without risk factors, but less so with them, especially cancer.
Area of Science:
- Cardiology
- Vascular Medicine
- Thrombosis Research
Background:
- The prognostic significance of distal deep vein thrombosis (DVT) location versus proximal DVT in relation to recurrence risk remains debated.
- It is unclear if distal DVT is an independent predictor of lower recurrence or a marker for underlying provoking factors of venous thromboembolism (VTE).
Purpose of the Study:
- To investigate the impact of distal DVT location on the risk of symptomatic, objectively confirmed recurrent VTE.
- To stratify patients based on the presence of transient or persistent risk factors for VTE.
Main Methods:
- A cohort of 831 patients with a first acute symptomatic DVT (without pulmonary embolism) was analyzed.
- Patients were stratified according to risk factors: transient, minor persistent, unprovoked, or cancer-associated.
- The primary outcome was symptomatic, objectively diagnosed recurrent VTE (including proximal DVT and pulmonary embolism).
Main Results:
- Overall, 15.0% of patients experienced recurrent DVT or PE.
- The strongest association between distal DVT and lower recurrence risk was observed in patients without identifiable risk factors (aHR: 0.11).
- In cancer patients, DVT location (distal vs. proximal) showed a comparable risk of recurrence (aHR: 0.70).
Conclusions:
- Distal DVT location is a favorable prognostic factor for recurrence in the absence of identifiable transient or persistent risk factors.
- The prognostic impact of DVT location on recurrence risk is diminished when persistent provoking factors, particularly cancer, are present.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
01:12Relative Risk
2.0K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
01:22Factors Influencing Attraction I: Proximity
252
Proximity plays a fundamental role in shaping interpersonal attraction by increasing opportunities for interaction and fostering familiarity. Research consistently demonstrates that individuals are more likely to form social bonds with those who are physically closer to them, whether in residential settings, workplaces, or educational institutions. This effect is largely driven by the increased frequency of encounters, which facilitates the development of friendships and romantic...
252
01:17Design Example: Analyzing Capacity Contours for Flood Risk Assessment
289
Flood risk assessment involves careful planning and analysis to ensure the safety of communities near water retention structures. Capacity contours are a vital tool in this process, as they illustrate the potential spread of water at specific levels in a given area. In the context of building a bund across a small valley, these contours play a critical role in evaluating the safety of nearby residential areas.In this example, the bund is intended to store stormwater in the valley. The engineers...
289
02:16Transcription Factors
82.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.3K
01:30Venous Thrombosis I: Introduction
415
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
415