Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.4K
Epigenetic Regulation01:46

Epigenetic Regulation

33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K
Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

5.0K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.0K
Relative Risk01:12

Relative Risk

2.0K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.3K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diabetes-induced TREM2-endothelial cell signaling impairs ischemic vascular repair.

Science translational medicine·2026
Same author

Syntaxin 4 protects islet β-cells from cytokine-induced senescence.

Frontiers in endocrinology·2026
Same author

Staying Functional Through Connection and Adaptation: When Islets Inspire Islet Biologists.

Diabetes·2026
Same author

Single-Cell Multimodal Profiling Highlights Persistent Aortic Smooth Muscle Cell Changes in Diabetic Mice Despite Glycemic Control.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Blood DNA methylation markers are associated with diabetic kidney disease progression in type 1 diabetes.

Diabetologia·2026
Same author

Metabolic beneficial effects of targeting a long non-coding RNA, lnc-megacluster, in obesity.

Molecular therapy. Nucleic acids·2026
Same journal

Continuous Glucose Monitoring in Type 2 Diabetes: Clinical Outcomes, Disparities in Access, and Cost-effectiveness.

Current diabetes reports·2026
Same journal

Beyond Inflammation - A Multidisciplinary Approach to Managing Obesity and Cardiometabolic Risk in Inflammatory Bowel Disease.

Current diabetes reports·2026
Same journal

Climate Change and Diabetes Outcomes: Evidence from Climate-Vulnerable Regions.

Current diabetes reports·2026
Same journal

Efficacy and safety of once-weekly basal insulin analogs versus daily basal insulin analogs in adults with type 2 diabetes: a systematic review and meta-analysis.

Current diabetes reports·2026
Same journal

Use of Glucagon-Like Peptide-1 Receptor Agonists in Women with Type 2 Diabetes Before Pregnancy: Addressing the Dilemma in A Real-World Setting.

Current diabetes reports·2026
Same journal

Can Behavioral Interventions Promote Health Equity in Pediatric Type 1 Diabetes? A Narrative Review of Promising Treatments.

Current diabetes reports·2026
See all related articles

Related Experiment Video

Updated: Jan 22, 2026

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

981

Epigenetics and Type 2 Diabetes Risk.

Sangeeta Dhawan1, Rama Natarajan2

  • 1Department of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.

Current Diabetes Reports
|June 29, 2019
PubMed
Summary
This summary is machine-generated.

Environmental factors influence type 2 diabetes (T2D) risk through epigenetic mechanisms. These changes can affect glucose homeostasis, be passed to offspring, and offer new therapeutic targets.

Keywords:
BiomarkersDiabetes complicationsEpigenetic therapiesEpigeneticsGlucose homeostasisType 2 diabetes

More Related Videos

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
10:17

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

7.4K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Related Experiment Videos

Last Updated: Jan 22, 2026

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice
03:17

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

981
An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
10:17

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

7.4K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Area of Science:

  • Endocrinology
  • Genetics
  • Environmental Health

Background:

  • Environmental factors significantly influence type 2 diabetes (T2D) risk.
  • Epigenetic mechanisms play a crucial role in T2D pathogenesis.
  • Epigenetic dysregulation is a key factor in T2D and its complications.

Purpose of the Study:

  • To review the role of epigenetic factors in T2D risk and pathogenesis.
  • To highlight how environmental factors induce epigenetic changes impacting T2D.

Main Methods:

  • Review of current literature on epigenetics and T2D.
  • Analysis of environmental influences on epigenetic modifications.
  • Examination of epigenome-wide association studies (EWAS) and epigenetic editing tools.

Main Results:

  • Environmental variations (lifestyle, nutrition) induce epigenetic changes affecting glucose homeostasis.
  • Epigenetic alterations can disrupt metabolic homeostasis and contribute to T2D.
  • Epigenetic changes may be heritable, increasing T2D risk across generations.

Conclusions:

  • Epigenetic dysregulation is central to T2D pathogenesis.
  • Advances in epigenetics offer opportunities for novel T2D biomarkers and interventions.
  • Targeting epigenetic mechanisms presents a promising therapeutic avenue for T2D.