Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.1K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.1K
Whole Body Regeneration01:33

Whole Body Regeneration

4.1K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
4.1K
Liver Regeneration01:24

Liver Regeneration

4.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.5K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.5K
Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

3.7K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long QT syndrome and hypoglycemia in a postbariatric surgery patient with a likely pathogenic variant in <i>KCNE1</i>.

JCEM case reports·2026
Same author

Insulin/IGF signaling in islet biology and its therapeutic implications.

Endocrine reviews·2026
Same author

Risk of falls and syncope across frailty levels in hypertensive older adults: a longitudinal study.

GeroScience·2026
Same author

Sarcopenia and Comorbidity Burden Independently Predict Cough Impairment in Hospitalized Patients: A Cross-Sectional Study.

Journal of clinical medicine·2026
Same author

Proteomic analyses of human islets reveal potential markers of β cell dysfunction during prediabetes.

JCI insight·2026
Same author

Trabecular bone score enhances fracture risk stratification in patients with metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus.

Journal of endocrinological investigation·2026

Related Experiment Video

Updated: Jan 22, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.0K

How, When, and Where Do Human β-Cells Regenerate?

Giorgio Basile1, Rohit N Kulkarni2, Noel G Morgan3

  • 1Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, 02215, USA. Giorgio.Basile@joslin.harvard.edu.

Current Diabetes Reports
|June 29, 2019
PubMed
Summary

Pancreatic beta-cells regulate glucose homeostasis but can be lost in diabetes. Research is exploring ways to regenerate these vital cells for diabetes treatment.

Keywords:
DiabetesIslets of LangerhansKi67ProliferationTransdifferentiationβ-Cell mass

More Related Videos

A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt
06:56

A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt

Published on: June 22, 2011

12.2K
Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration
11:48

Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration

Published on: May 7, 2018

10.9K

Related Experiment Videos

Last Updated: Jan 22, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.0K
A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt
06:56

A System for Culturing Iris Pigment Epithelial Cells to Study Lens Regeneration in Newt

Published on: June 22, 2011

12.2K
Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration
11:48

Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration

Published on: May 7, 2018

10.9K

Area of Science:

  • Endocrinology
  • Metabolism
  • Cell Biology

Background:

  • Pancreatic beta-cells are crucial for insulin secretion and maintaining glucose homeostasis.
  • Beta-cell dysfunction or loss leads to hyperglycemia and diabetes.
  • Beta-cell mass is primarily established postnatally and typically does not expand significantly in adulthood.

Purpose of the Study:

  • To review recent findings on factors influencing pancreatic beta-cell replication and replenishment.
  • To explore therapeutic strategies for manipulating beta-cell mass in diabetes treatment.

Main Methods:

  • Review of current physiological and pharmacological research on beta-cell regeneration.
  • Analysis of studies investigating neogenesis and transdifferentiation as sources of new beta-cells.

Main Results:

  • Identification of potential physiological and pharmacological agents that can stimulate beta-cell replication.
  • Evidence suggesting that neogenesis and transdifferentiation may contribute to beta-cell replenishment.
  • Progress in understanding the mechanisms that control beta-cell mass.

Conclusions:

  • Stimulating beta-cell replication and replenishment holds promise for diabetes therapy.
  • Further research into controlled manipulation of beta-cell mass is essential for therapeutic success.
  • Regenerating pancreatic beta-cells represents a significant goal for future diabetes interventions.