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STIP1 Tissue Expression Is Associated with Survival in Chemotherapy-Treated Bladder Cancer Patients
U Krafft1, S Tschirdewahn1, J Hess1
1Department of Urology, West German Cancer Center, University of Duisburg-Essen, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Pathology Oncology Research : POR
|June 29, 2019
Summary
Tissue STIP1 expression may predict cisplatin resistance in advanced bladder cancer (BC). Nuclear STIP1 staining correlated with poorer overall survival (OS), while cytoplasmic staining linked to shorter progression-free survival (PFS).
Area of Science:
- Oncology
- Biomarker Research
- Cancer Therapeutics
Background:
- Cisplatin-based chemotherapy is a standard treatment for advanced bladder cancer (BC).
- Predictive biomarkers are crucial for identifying patients likely to resist cisplatin therapy, guiding treatment decisions.
- Novel immunooncologic agents offer alternatives for cisplatin-resistant or ineligible patients.
Purpose of the Study:
- To evaluate the predictive value of Stress-Induced Phosphoprotein 1 (STIP1) in relation to cisplatin chemotherapy in advanced bladder cancer.
- To determine if STIP1 expression in tumor tissue or serum can predict treatment response and patient outcomes.
Main Methods:
- Immunohistochemistry was used to analyze STIP1 expression in paraffin-embedded bladder cancer tissues from 98 patients.
- Pre-chemotherapy serum STIP1 concentrations were measured using ELISA in 48 BC patients.
- Results were correlated with clinicopathological data and patient follow-up information.
Main Results:
- Stronger STIP1 nuclear staining was significantly associated with worse overall survival (OS) (p=0.034) and shorter progression-free survival (PFS) (p=0.045).
- Increased STIP1 cytoplasmic immunostaining correlated with shorter PFS (p=0.026) in patients receiving at least two chemotherapy cycles.
- Elevated serum STIP1 levels were linked to older patient age but showed no correlation with patient outcome or chemotherapy response.
Conclusions:
- Tissue STIP1 analysis, particularly nuclear and cytoplasmic staining patterns, shows potential as a predictive biomarker for cisplatin resistance in advanced bladder cancer.
- Pre-treatment serum STIP1 levels do not appear to have predictive value for chemotherapy response or survival in BC patients.
- Further research into tissue STIP1 expression could optimize treatment selection for advanced bladder cancer patients undergoing cisplatin chemotherapy.
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