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Secondary Metabolites from Deep-Sea Derived Microorganisms
Chunxiao Sun1, Shah Mudassir1, Zhenzhen Zhang1
1Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.R. China
Current Medicinal Chemistry
|June 29, 2019
Summary
Deep-sea microbes yield novel natural products with significant bioactivities, including cytotoxicity. This review highlights 442 compounds discovered by 2017, aiding the search for new pharmaceutical agents.
Area of Science:
- Marine Microbiology
- Natural Product Chemistry
- Drug Discovery
Background:
- Deep-sea microorganisms are prolific sources of unique marine natural products.
- These compounds often possess novel chemical structures and diverse biological activities.
Purpose of the Study:
- To review outstanding research on deep-sea microbial natural products up to 2017.
- To summarize structural characteristics, bioactivities, and origins of these compounds.
- To facilitate the discovery of novel pharmaceutical agents from the deep sea.
Main Methods:
- Retrospective analysis of published research on deep-sea microbial natural products.
- Compilation of data on compound structures, biological activities, and source microorganisms.
- Categorization of compounds based on bioactivity, particularly cytotoxicity.
Main Results:
- A total of 442 compounds were identified by the end of 2017.
- Approximately 60% of these compounds exhibit various biological activities.
- Over 30% of the identified compounds demonstrate cytotoxic functions.
Conclusions:
- Deep-sea microbial natural products represent a valuable resource for drug discovery.
- Understanding their structural and biological properties is crucial for pharmaceutical development.
- Further exploration of deep-sea microorganisms is warranted for novel therapeutic agents.
Keywords:
Deep-sea-derived microorganismsantibacterialbiological activitycytotoxicnatural productssecondary metabolitesMore Related Videos
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