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Published on: July 29, 2015
Early conversion of classic Fontan conversion may decrease term morbidity: single centre outcomes
David Blitzer1, Asma S Habib1, John W Brown1
1Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA.
Insights
Fontan conversion can improve outcomes for adults with Fontan complications. Early conversion is recommended before severe heart failure develops, offering an acceptable risk profile for this complex procedure.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Adult Congenital Heart Disease
Background:
- The classic Fontan procedure has historically led to complications in adults.
- Total cavopulmonary connection is the current standard palliation for univentricular hearts in children.
- Adults with Fontan-associated complications may benefit from conversion to a total cavopulmonary connection.
Purpose of the Study:
- To evaluate the outcomes of Fontan conversion procedures in adults.
- To determine the safety and efficacy of converting classic Fontan to total cavopulmonary connection.
- To identify optimal timing for Fontan conversion based on patient presentation.
Main Methods:
- Retrospective chart review of Fontan conversion procedures from July 1999 to January 2017.
- Analysis of patient demographics, reasons for conversion, and early outcomes (mortality, heart transplant).
- Evaluation of survival rates at 30 days, 1 year, and beyond post-conversion.
Main Results:
- 41 patients underwent Fontan conversion, with an average age of 24.5 years.
- Common indications included atrial arrhythmias (90.2%) and heart failure (75.6%).
- Survival rates were high: 95.1% at 30 days, 92.7% at 1 year, and 87.8% long-term; two patients required heart transplant.
Conclusions:
- Fontan conversion is a viable option for adults with complications from the initial Fontan procedure.
- Early consideration for conversion is advised when atrial arrhythmias arise, rather than awaiting severe heart failure.
- Fontan conversion can be performed with an acceptable risk profile.
Background:
The initial classic Fontan utilising a direct right atrial appendage to pulmonary artery anastomosis led to numerous complications. Adults with such complications may benefit from conversion to a total cavo-pulmonary connection, the current standard palliation for children with univentricular hearts.
Methods:
A single institution, retrospective chart review was conducted for all Fontan conversion procedures performed from July, 1999 through January, 2017. Variables analysed included age, sex, reason for Fontan conversion, age at Fontan conversion, and early mortality or heart transplant within 1 year after Fontan conversion.
Results:
A total of 41 Fontan conversion patients were identified. Average age at Fontan conversion was 24.5 ± 9.2 years. Dominant left ventricular physiology was present in 37/41 (90.2%) patients. Right-sided heart failure occurred in 39/41 (95.1%) patients and right atrial dilation was present in 33/41 (80.5%) patients. The most common causes for Fontan conversion included atrial arrhythmia in 37/41 (90.2%), NYHA class II HF or greater in 31/41 (75.6%), ventricular dysfunction in 23/41 (56.1%), and cirrhosis or fibrosis in 7/41 (17.1%) patients. Median post-surgical follow-up was 6.2 ± 4.9 years. Survival rates at 30 days, 1 year, and greater than 1-year post-Fontan conversion were 95.1, 92.7, and 87.8%, respectively. Two patients underwent heart transplant: the first within 1 year of Fontan conversion for heart failure and the second at 5.3 years for liver failure.
Conclusions:
Fontan conversion should be considered early when atrial arrhythmias become common rather than waiting for severe heart failure to ensue, and Fontan conversion can be accomplished with an acceptable risk profile.
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