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Clinical study on the pharmacokinetics of lithium carbonate
1Shanghai Mental Health Center, Shanghai Testing Technology Institute, Shanghai Medical University, People's Republic of China.
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|December 1, 1987
Abstract:
To investigate clinical pharmacokinetics of lithium carbonate, 28 hospitalized mental patients and 8 healthy volunteers were studied. The serum concentration/time profile in the single dose peroral experiments could be fitted to a pharmacokinetic model using an open two compartmental system. Three methods, 72-h and 24-h residual method and Ritschel's repeated one-point method were used and the results compared with one another. According to the results of this paper, we suggest the use of Ritschel's repeated one-point method for clinical dosage regimen determination.