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Updated: Jan 22, 2026

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
Published on: October 4, 2024
Phytochemical-Based Nanocomposites for the Treatment of Bacterial Biofilms
Cheng-Hsuan Li1, Xinhong Chen2, Ryan F Landis1
1Department of Chemistry , University of Massachusetts Amherst , 710 North Pleasant Street , Amherst , Massachusetts 01003 , United States.
Abstract:
Biofilm infections are responsible for at least 65% of human bacterial infections. These biofilms are refractory to conventional antibiotics, leading to chronic infections and nonhealing wounds. Plant-derived antibiotics (phytochemicals) are promising alternative antimicrobial treatments featuring antimicrobial properties. However, their poor solubility in aqueous media limits their application in treating biofilm infections. Phytochemicals were incorporated into cross-linked polymer nanocomposite "sponges" for the treatment of bacterial biofilms. The results indicated encapsulating low log P phytochemicals effectively eliminated biofilms while demonstrating low cytotoxicity against mammalian fibroblast cells.
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