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Curing of Concrete01:20

Curing of Concrete

354
The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
354
Curing Methods01:26

Curing Methods

284
Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
284
Accelerated Curing of Concrete01:25

Accelerated Curing of Concrete

454
Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
454
Avoidance Learning and Learned Helplessness01:14

Avoidance Learning and Learned Helplessness

2.5K
Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
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Learning Disabilities01:25

Learning Disabilities

580
Learning disabilities are cognitive disorders caused by neurological impairments that affect cognitive functions like language and reading, without indicating overall intellectual or developmental challenges. These disabilities differ from global intellectual or developmental disabilities as they are limited to distinct cognitive functions. Common learning disabilities include dysgraphia, dyslexia, and dyscalculia, each of which impacts unique aspects of learning.
Dyslexia
Dyslexia is a...
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Associative Learning01:27

Associative Learning

1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
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Related Experiment Video

Updated: Jan 22, 2026

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
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Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

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Elite controllers and lessons learned for HIV-1 cure.

Cecilio Lopez-Galindez1, Maria Pernas1, Concepcion Casado1

  • 1Virología Molecular, Laboratorio de Referencia e Investigación en Retrovirus, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

Current Opinion in Virology
|June 29, 2019
PubMed
Summary

Long-term non-progressors, particularly Elite Controllers, offer hope for an HIV-1 cure. Analysis suggests these individuals may have achieved a functional cure through a combination of host, immune, and viral factors.

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Area of Science:

  • Immunology
  • Virology
  • Genetics

Background:

  • Antiviral treatments have successfully suppressed HIV-1 replication, making a cure the next goal.
  • Long-term non-progressors (LTNPs) and Elite Controllers (LTNP EC) spontaneously control HIV-1, offering insights into potential cures.
  • Understanding host genetics, immune responses, and viral factors is crucial for HIV-1 control.

Purpose of the Study:

  • To analyze mechanisms of viral control in LTNP EC.
  • To identify factors contributing to prolonged HIV-1 control.
  • To propose a functional cure model for HIV-1 infection.

Main Methods:

  • Review of multiple studies on LTNP EC.
  • Analysis of host protective factors, immune responses, and viral genetic variability.
  • Assessment of clinical parameters including CD4+ cell counts and disease progression.

Main Results:

  • LTNP EC exhibit prolonged viral control (20-30 years) without clinical progression.
  • These individuals maintain high CD4+ cell counts (>400-500 cells/μl).
  • A combination of host, immune, and viral factors contributes to sustained control.

Conclusions:

  • HIV-1 cure remains challenging, but a functional cure is a more feasible objective.
  • LTNP EC with specific characteristics may represent a functional cure for HIV-1.
  • Further research into these factors can guide the development of functional cure strategies.