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Updated: Jan 22, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Acute myocardial infarction associated with initial alemtuzumab infusion cycle in relapsing-remitting multiple
Meghan C Romba1, Scott D Newsome2, Justin C McArthur3
1Providence Neurological Specialties, Neurology-Multiple Sclerosis Attending, Providence St. Vincent Medical Center, Portland, OR, United States.
Abstract:
Alemtuzumab is an anti-CD52 monoclonal antibody used for the treatment of lymphoproliferative disorders and relapsing-remitting multiple sclerosis. We report a 30-year-old woman with relapsing-remitting multiple sclerosis who developed a type 2 non-ST elevated myocardial infarction (NSTEMI) during her first alemtuzumab infusion cycle. While acute coronary syndrome has been described with alemtuzumab in the treatment of lymphoma, alemtuzumab-associated cardiac ischemia in multiple sclerosis is uncommon and can occur in patients without cardiovascular risk factors.
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