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Updated: Jan 22, 2026

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
Published on: November 30, 2018
Identification of Functional Domains on the 1,25-Dihydroxyvitamin-D3 Receptor
Abstract:
Functional domains of the 50 kDa (427 amino acid residues) of the human 1,25-dihydroxyvitamin D3 receptor necessary for stimulation of osteocalcin gene transcription were mapped. Amino acid residues 1-144 comprise the DNA-binding domain, while the C-terminal 114 residues define the 1,25(OH)2D3 ligand binding domain. In the 5'-promoter region of the human osteocalcin gene, a specific 21-base-pair DNA element (-489 to -509) was identified as the specific site of binding of the DNA-binding domain of the 1,25(OH)2D3 receptor.
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