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Very slightly deleterious mutations and the molecular clock.

T Ohta1

  • 1National Institute of Genetics, Mishima, Japan.

Journal of Molecular Evolution
|January 1, 1987
PubMed
Summary

Slightly harmful mutations influence the molecular evolutionary clock. Evolutionary rates correlate negatively with population size, a finding partially offset by generation time effects on mutation rates.

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Area of Science:

  • Population genetics
  • Molecular evolution
  • Genomics

Background:

  • The molecular evolutionary clock hypothesis posits a constant rate of molecular evolution.
  • Understanding the impact of slightly deleterious mutations is crucial for refining evolutionary clock models.
  • Selection coefficients for mutations with small effects are key parameters in population genetics.

Purpose of the Study:

  • To examine the model of very slightly deleterious mutations within population genetics.
  • To investigate the relationship between these mutations and the molecular evolutionary clock.
  • To determine the impact of population size and environmental diversity on evolutionary rates.

Main Methods:

  • Analysis of selection coefficients for amino acid changes.
  • Modeling the distribution and variance of selection coefficients.
  • Considering environmental diversity and species' total population size.
  • Evaluating the interplay between evolutionary rate, population size, and intrinsic mutation rate.

Main Results:

  • The distribution of selection coefficients for slightly deleterious mutations is continuous around zero, with a negative average.
  • Variance in selection coefficients is linked to environmental diversity and population size.
  • A negative correlation between evolutionary rate and population size is predicted.
  • Generation time effects on intrinsic mutation rate partially counteract the population size effect.

Conclusions:

  • Slightly deleterious mutations significantly impact molecular evolutionary clock predictions.
  • Population size is a critical factor influencing evolutionary rates.
  • The model provides a framework for understanding molecular evolution dynamics and clock calibration.

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