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Related Experiment Videos

Total parental nutrition using conventional and medium chain triglycerides: effect on liver function tests,

A R Dennison1, M Ball, L J Hands

  • 1Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford, England.

JPEN. Journal of Parenteral and Enteral Nutrition
|January 1, 1988
PubMed
Summary

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A new lipid emulsion with medium chain triglycerides (MCT/LCT) improved nitrogen balance and lowered bilirubin levels compared to conventional long chain triglycerides (LCT). This suggests MCT/LCT may offer nutritional benefits in clinical settings.

Area of Science:

  • Nutritional Science
  • Biochemistry
  • Clinical Nutrition

Background:

  • Long chain triglycerides (LCT) are commonly used in parenteral nutrition.
  • Medium chain triglycerides (MCT) have different metabolic properties compared to LCT.
  • The clinical efficacy and safety of MCT/LCT emulsions require further investigation.

Purpose of the Study:

  • To compare the effects of a novel MCT/LCT emulsion with conventional LCT emulsion on key biochemical markers.
  • To evaluate the impact of MCT/LCT on nitrogen balance and plasma bilirubin levels.

Main Methods:

  • A randomized cross-over trial was conducted over 10 days.
  • Participants received either LCT or a 5% MCT/5% LCT emulsion.
  • Plasma levels of albumin, prealbumin, complement components (C3, C4), and prothrombin times were monitored daily.

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  • Liver enzymes (AST, ALP) and bilirubin levels were assessed.

    • Main Results:

    • No significant changes in albumin, prealbumin, or prothrombin times were observed between the two lipid regimens.
    • Aspartate transaminase and alkaline phosphatase activities remained similar across both periods.
    • A transient increase in C3 and C4 levels was noted after 5 hours of lipid infusion for both LCT and MCT/LCT.
    • The MCT/LCT regimen resulted in improved nitrogen balance and lower plasma bilirubin levels compared to LCT.

    Conclusions:

    • The MCT/LCT emulsion was well-tolerated, showing no adverse effects on liver enzymes or coagulation parameters.
    • The improved nitrogen balance and reduced bilirubin levels suggest potential metabolic advantages of MCT/LCT.
    • Further research is warranted to explore the long-term clinical benefits of MCT/LCT in various patient populations.