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Updated: Jan 22, 2026

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Surface plasmon resonance biosensor for the ultrasensitive detection of bisphenol A
Chadtová Song Xue1, Gedeonová Erika1, Homola Jiří2
1Institute of Photonics and Electronics, Czech Academy of Sciences, Chaberská 57, 182 51, Prague, Czech Republic.
Abstract:
Bisphenol A (BpA) is a chemical that is extensively used in common plastic products, such as food and drink containers. It can leach from the plastics and penetrate into the human body, where it acts as an endocrine disruptor with significant risks to human health. In order to minimize the exposure of human populations to BpA, methods for the detection of BpA are needed. In this work, we present a novel surface plasmon resonance (SPR) biosensor for ultrasensitive detection of BpA. Our approach combines a binding inhibition assay with functionalized gold nanoparticles for the enhancement of sensor response. We demonstrate that the developed biosensor enables the detection of BpA in a wide range of concentrations (0.01 to 100,000 ng/mL) with an extremely low limit of detection-5.2 pg/mL.
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