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Capecitabine induced fingerprint changes.

Ali Yaghobi Joybari1, Payam Azadeh1, Hosein A Ghiasi1

  • 1Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Clinical Pharmacy and Therapeutics
|June 30, 2019
PubMed
Summary

Chemotherapy with capecitabine can cause fingerprint changes in most patients, unrelated to hand and foot syndrome. Patients should be informed of this risk before treatment due to potential legal implications.

Keywords:
capecitabinefingerprint changesfingerprint recognitionhand and foot syndrome

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Area of Science:

  • Oncology
  • Dermatology
  • Forensic Science

Background:

  • Fingerprints are crucial for personal identification.
  • Certain chemotherapy agents, like capecitabine, can cause hand and foot syndrome (HFS), potentially damaging fingerprints.
  • Fingerprint alterations may occur independently of HFS.

Purpose of the Study:

  • To investigate the incidence of fingerprint changes in patients undergoing capecitabine-based chemotherapy.
  • To determine the relationship between capecitabine treatment, HFS, and fingerprint alterations.

Main Methods:

  • Seventy-one patients receiving chemotherapy (with or without capecitabine) were enrolled.
  • Fingerprints were collected pre-chemotherapy and after the third cycle.
  • Fingerprint changes were assessed by forensic physicians.

Main Results:

  • Fingerprint changes were observed in 67.6% of patients in the capecitabine group (25/37), versus none in the comparison group.
  • No correlation was found between the presence or severity of HFS and fingerprint changes (P=0.880).
  • Capecitabine dosage and course number did not significantly correlate with fingerprint changes.

Conclusions:

  • Capecitabine therapy is associated with a high incidence of fingerprint changes.
  • These changes are not directly linked to the severity of hand and foot syndrome.
  • Patients commencing capecitabine should be counseled on the risk of fingerprint alterations due to potential legal implications.