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Updated: Jan 22, 2026
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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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Anaplastic Oligodendroglioma with Transdural Extension
Ai Peng Tan1, Char Loo Tan2, Yin Huei Pang2
1Department of Diagnostic Imaging, National University Health System, Singapore.
World Neurosurgery
|June 30, 2019
Summary
This report details a rare anaplastic oligodendroglioma with transdural extension, a finding not previously documented without prior surgery or radiation. Understanding this rare presentation may improve glioma diagnosis and treatment.
Area of Science:
- Neuro-oncology
- Molecular Pathology
Background:
- Oligodendrogliomas are defined by isocitrate dehydrogenase (IDH) mutation and 1p19q codeletion.
- They represent the third most common primary brain tumor.
Observation:
- An extremely rare case of an anaplastic oligodendroglioma with transdural extension into the frontal and ethmoid sinuses is presented.
- This unusual presentation occurred without prior neurosurgical intervention or radiotherapy.
Findings:
- The tumor exhibited a molecular profile consistent with oligodendroglioma.
- This represents the first reported instance of transdural extension in a molecularly defined oligodendroglioma without prior intervention.
Implications:
- This case expands the understanding of oligodendroglioma behavior and potential spread patterns.
- Further research is needed to explore the link between oligodendroglioma molecular subtypes and transdural extension incidence.
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