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From Perception Threshold to Ion Channels-A Computational Study.
Jenny Tigerholm1, Aida Hejlskov Poulsen1, Ole Kæseler Andersen1
1Center of Neuroplasticity and Pain, SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Biophysical Journal
|July 1, 2019
Summary
Small electrodes preferentially activate pain receptors, unlike large ones. Computational models show differences in ion channel distribution and nerve ending structure explain varied perception thresholds between electrode types.
Area of Science:
- Neuroscience
- Computational Biology
- Biophysics
Background:
- Small-surface-area electrodes selectively activate cutaneous nociceptors, contrasting with large electrodes that activate non-nociceptive fibers.
- Distinct perception thresholds observed with different electrode sizes suggest varying nerve excitability properties.
Purpose of the Study:
- Investigate the origins of perception threshold differences between small and large cutaneous electrodes.
- Hypothesize that variations in voltage-gated ion channel distribution and peripheral nerve ending morphology underlie these threshold differences.
Main Methods:
- Developed a two-part computational model: a finite-element model for extracellular fields and a multicompartment axon model (Aδ and Aβ).
- Incorporated diverse voltage-gated ion channels (NaTTXs, NaTTXr, Nap, Kdr, KM, KA, HCN) into the detailed axon models.
Main Results:
- The computational model successfully replicated experimentally determined perception thresholds for strength-duration, threshold electrotonus, and slow pulse forms.
- Results support the hypothesis that differences in ion channel distribution and fiber morphology are sufficient to explain varied perception thresholds.
Conclusions:
- Perception threshold assessments may indirectly measure membrane excitability.
- Computational models offer a potential link between voltage-gated ion channel activation and measured perception thresholds.
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