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Updated: Jan 22, 2026

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
09:44

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

639

Recent advances of induced pluripotent stem cells application in neurodegenerative diseases

Nashwa Amin1, Xiaoning Tan2, Qiannan Ren2

  • 1Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China; Department of Zoology, Faculty of Science, Aswan University, Egypt.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|July 1, 2019
PubMed

Insights

Induced pluripotent stem cells (iPSCs) offer a powerful model for studying neurodegenerative diseases like Alzheimer's and Parkinson's. This review explores iPSC applications in modeling these conditions and highlights the role of autophagy.

Area of Science:

  • Stem cell biology
  • Neuroscience
  • Genetics

Background:

  • Stem cells possess self-renewal and differentiation capabilities.
  • Pluripotent stem cells, including induced pluripotent stem cells (iPSCs), mimic embryonic stem cells.
  • iPSCs are reprogrammed adult cells retaining pluripotency.

Purpose of the Study:

  • To review the use of iPSCs in modeling neurodegenerative diseases.
  • To discuss specific disease models like Alzheimer's, Parkinson's, and multiple sclerosis.
  • To highlight the significance of autophagy in neurodegeneration.

Main Methods:

  • Utilizing induced pluripotent stem cells (iPSCs) for disease modeling.
  • Differentiating iPSCs into neural cell types and organoids.
  • Analyzing genetic mutations and cellular mechanisms in disease models.

Main Results:

  • iPSCs provide a viable platform for studying neurodegenerative disorders.
  • Disease-specific mutations can be modeled using patient-derived iPSCs.
  • Autophagy plays a crucial role in the pathogenesis of neurodegenerative diseases.

Conclusions:

  • iPSC technology is instrumental in advancing our understanding of neurodegenerative diseases.
  • iPSC-derived neural models facilitate the investigation of disease mechanisms and potential therapies.
  • Targeting autophagy may offer therapeutic strategies for neurodegenerative conditions.

Keywords:
Alzheimer’s disease (AD)AutophagyInduced pluripotent stem cells (iPSCs)Neurodegenerative diseasesParkinson’s disease (PD)

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