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Ventral striatum and stuttering: Robust evidence from a case-control study applying DARTEL
Christian Montag1, Benjamin Bleek2, Martin Reuter3
1Department of Molecular Psychology, Institute of Psychology and Education, Ulm University, Germany.
Neuroimage. Clinical
|July 1, 2019
Summary
Developmental stuttering may involve basal ganglia differences. This study found higher gray matter volume in the right caudate and putamen in people who stutter, supporting basal ganglia dysfunction theories.
Area of Science:
- Neuroscience
- Speech and Language Pathology
- Neuroimaging
Background:
- Developmental stuttering is linked to basal ganglia dysfunction, but studies on gray matter volume show inconsistent results.
- Previous research on brain structure differences in people who stutter is often limited by small sample sizes and less advanced statistical methods.
Purpose of the Study:
- To investigate gray matter volume differences in the basal ganglia between individuals who stutter and control participants using advanced neuroimaging techniques.
- To clarify the role of the basal ganglia in the neural mechanisms underlying developmental stuttering.
Main Methods:
- Utilized the DARTEL algorithm (Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra) for advanced brain data analysis.
- Compared a sample of 36 people who stutter with 34 control participants.
Main Results:
- Found significantly higher gray matter volume in the right caudate and putamen regions of the basal ganglia in individuals who stutter.
- Results align with previous findings of increased gray matter volume in the right nucleus accumbens in people who stutter.
Conclusions:
- The findings support the theory that basal ganglia dysfunction plays a key role in developmental stuttering.
- Observed gray matter differences may reflect compensatory brain mechanisms or effects of stuttering treatment.
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