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Early Onset Hypertension Is Associated With Hypertensive End-Organ Damage Already by MidLife
Karri Suvila1, Elizabeth L McCabe2, Arttu Lehtonen3
1From the Division of Medicine, Turku University Hospital (K.S., T.J.N.), University of Turku, Finland.
Hypertension (Dallas, Tex. : 1979)
|July 2, 2019
Summary
Early hypertension (before age 35) significantly increases the risk of target organ damage by midlife. Identifying the age of hypertension onset is crucial for predicting and preventing cardiovascular complications.
Area of Science:
- Cardiology
- Public Health
- Hypertension Research
Background:
- Early onset hypertension is linked to increased cardiovascular mortality.
- The impact of early hypertension on target end-organ damage (TOD) by midlife remains unclear.
Purpose of the Study:
- To investigate the association between the age of hypertension onset and the development of TOD in middle-aged adults.
- To identify individuals at higher risk for hypertensive complications based on hypertension onset age.
Main Methods:
- Analysis of 2680 participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study.
- Assessed blood pressure, echocardiographic left ventricular hypertrophy, coronary calcification, albuminuria, and diastolic dysfunction.
- Used logistic regression to determine odds ratios for TOD based on hypertension onset age groups (<35, 35-44, ≥45 years).
Main Results:
- Hypertension onset before age 35 was significantly associated with increased odds of left ventricular hypertrophy (OR 2.29), coronary calcification (OR 2.94), and diastolic dysfunction (OR 2.06).
- Albuminuria showed a trend towards increased odds (OR 1.12) with early hypertension onset.
- Hypertension onset at age ≥45 years was not associated with increased odds of TOD.
Conclusions:
- Early onset hypertension, particularly before age 35, is a significant risk factor for developing target end-organ damage by midlife.
- Assessing the age of hypertension onset is vital for risk stratification and targeted prevention of cardiovascular complications.
- These findings highlight the importance of early hypertension detection and management.
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