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Solid cell nests (SCN) in Hashimoto's thyroiditis.
1Institute of Pathology, University of Zurich, University Hospital, Switzerland.
Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1988
Summary
Epidermoid cell nests in Hashimoto's thyroiditis share characteristics with solid cell nests (SCN). These findings suggest a closer resemblance to SCN than to squamous metaplasia of follicular cells.
Area of Science:
- Endocrinology
- Surgical Pathology
- Immunohistochemistry
Background:
- Squamous metaplasia is observed in Hashimoto's thyroiditis.
- These foci resemble thyroid's solid cell nests (SCN), believed to be remnants of the fourth endodermal pouch.
- SCN are identifiable by histology and positive reaction with polyclonal anti-carcinoembryonic antigen (CEA).
Purpose of the Study:
- To investigate the nature of epidermoid cell nests in Hashimoto's thyroiditis.
- To compare these nests with SCN and follicular cell metaplasia using immunohistochemistry.
Main Methods:
- Systematic examination of H&E-stained histological sections from 79 Hashimoto's thyroiditis cases.
- Immunohistochemical analysis for thyroglobulin, CEA (polyclonal and monoclonal), calcitonin, chromogranin, keratin, and Lu-5 epitope in identified cell nests.
Main Results:
- Three types of cell nests were identified in 39 cases.
- 73% of the second and third types of nests showed positivity for polyclonal CEA.
- Immunohistochemistry revealed positivity for monoclonal CEA (3/15), keratin (5/14), and Lu-5 (13/15), but not for thyroglobulin, calcitonin, or chromogranin.
Conclusions:
- Epidermoid cell nests in Hashimoto's thyroiditis exhibit characteristics aligning more closely with SCN.
- The findings differentiate these nests from typical squamous metaplasia of follicular cells.