Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solid cell nests (SCN) in Hashimoto's thyroiditis.

I Vollenweider1, C Hedinger

  • 1Institute of Pathology, University of Zurich, University Hospital, Switzerland.

Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contusio cordis with late rupture of the left ventricle.

Cardiologia·2010
Same author

About a case of retrograde intestinal vaginal invasion after gastroenterostomy.

Helvetica chirurgica acta·2010
Same author

Proliferation of IL-2 activated lymphocytes preferably occurs in aggregates by cells expressing the CD57 antigen.

Scandinavian journal of immunology·1995
Same author

Development of four donor-specific phenotypes in human long-term lymphokine-activated killer cell cultures.

Cancer immunology, immunotherapy : CII·1994
Same author

Heterogeneous binding and killing behaviour of human gamma/delta-TCR+ lymphokine-activated killer cells against K562 and Daudi cells.

Cancer immunology, immunotherapy : CII·1993
Same author

Comparison of four DNA staining fluorescence dyes for measuring cell proliferation of lymphokine-activated killer (LAK) cells.

Journal of immunological methods·1992
Same journal

Three familial cases of fundic gland polyposis without polyposis coli.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
Same journal

Myopathy and hypertrophic cardiomyopathy with selective lysis of thick filaments.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
Same journal

Alpha-smooth muscle actin and other stromal markers in endometrial mucosa.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
Same journal

Foamy spheroid bodies in the globus pallidus and the substantia nigra pars reticulata: an investigation on regional distribution in 56 cases without neurodegenerative diseases.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
Same journal

Nature and significance of calcium oxalate crystals in normal human thyroid gland. A clinicopathological and immunohistochemical study.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
Same journal

Longitudinally oriented smooth muscle cells in rabbit arteries.

Virchows Archiv. A, Pathological anatomy and histopathology·1993
See all related articles

Epidermoid cell nests in Hashimoto's thyroiditis share characteristics with solid cell nests (SCN). These findings suggest a closer resemblance to SCN than to squamous metaplasia of follicular cells.

Area of Science:

  • Endocrinology
  • Surgical Pathology
  • Immunohistochemistry

Background:

  • Squamous metaplasia is observed in Hashimoto's thyroiditis.
  • These foci resemble thyroid's solid cell nests (SCN), believed to be remnants of the fourth endodermal pouch.
  • SCN are identifiable by histology and positive reaction with polyclonal anti-carcinoembryonic antigen (CEA).

Purpose of the Study:

  • To investigate the nature of epidermoid cell nests in Hashimoto's thyroiditis.
  • To compare these nests with SCN and follicular cell metaplasia using immunohistochemistry.

Main Methods:

  • Systematic examination of H&E-stained histological sections from 79 Hashimoto's thyroiditis cases.
  • Immunohistochemical analysis for thyroglobulin, CEA (polyclonal and monoclonal), calcitonin, chromogranin, keratin, and Lu-5 epitope in identified cell nests.

Related Experiment Videos

Main Results:

  • Three types of cell nests were identified in 39 cases.
  • 73% of the second and third types of nests showed positivity for polyclonal CEA.
  • Immunohistochemistry revealed positivity for monoclonal CEA (3/15), keratin (5/14), and Lu-5 (13/15), but not for thyroglobulin, calcitonin, or chromogranin.

Conclusions:

  • Epidermoid cell nests in Hashimoto's thyroiditis exhibit characteristics aligning more closely with SCN.
  • The findings differentiate these nests from typical squamous metaplasia of follicular cells.