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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

16.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Base Excision Repair01:54

Base Excision Repair

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
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Base Excision Repair01:54

Base Excision Repair

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Nucleotide Excision Repair01:08

Nucleotide Excision Repair

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Overview
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Related Experiment Video

Updated: Jan 22, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
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Inflammatory response after transanal total mesorectal excision.

Mahdi Alamili1, Katarina Levic, Katrine Kanstrup

  • 1orhan.bulut@regionh.dk.

Danish Medical Journal
|July 2, 2019
PubMed
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Transanal total mesorectal excision (taTME) shows no difference in post-operative inflammatory response compared to conventional laparoscopic surgery (CLS) and single-port laparoscopic surgery (SPLS). Surgical trauma is not solely dependent on abdominal incision length in minimally invasive rectal cancer surgery.

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Area of Science:

  • Colorectal Surgery
  • Surgical Oncology
  • Minimally Invasive Surgery

Background:

  • Transanal total mesorectal excision (taTME) potentially reduces hernia rates and surgical trauma.
  • Comparison of post-operative immune response between taTME, conventional laparoscopic surgery (CLS), and single-port laparoscopic surgery (SPLS) is investigated.

Purpose of the Study:

  • To compare the post-operative immune response in patients undergoing taTME versus CLS and SPLS for rectal cancer.
  • To evaluate if taTME offers a reduced inflammatory stress response compared to other minimally invasive techniques.

Main Methods:

  • A comparative cohort study involving patients with rectal cancer undergoing taTME, CLS, or SPLS.
  • Measurement of C-reactive protein (CRP) and white blood cell count (WBC) pre-operatively and on post-operative days 1-4.

Main Results:

  • Demographics, R0 resection, and complication rates were comparable across groups (n=40 taTME, n=20 CLS, n=20 SPLS).
  • taTME resulted in a significantly shorter abdominal incision length compared to CLS and SPLS.
  • While CRP and WBC levels increased significantly in all groups, no significant differences were observed between taTME, CLS, and SPLS.

Conclusions:

  • There is no discernible difference in the post-operative inflammatory response among taTME, CLS, and SPLS for rectal cancer.
  • The length or presence of an abdominal incision does not appear to be the sole determinant of post-operative inflammatory stress in minimally invasive procedures.
  • Surgical trauma in minimally invasive rectal cancer surgery is influenced by factors beyond the abdominal incision, including intra-abdominal tissue handling.