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Early lead exposure and childhood adiposity in Mexico city

Yun Liu1, Karen E Peterson1, Kathleen Montgomery2

  • 1Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.

International Journal of Hygiene and Environmental Health
|July 2, 2019
PubMed

Insights

Prenatal lead exposure was linked to lower body fat and smaller measurements in Mexican children. This suggests early lead exposure may influence fetal growth programming, warranting further investigation into biological mechanisms.

Area of Science:

  • Environmental Health
  • Pediatric Endocrinology
  • Toxicology

Background:

  • Prenatal and early childhood lead exposure are linked to reduced infant weight.
  • Research on lead exposure's impact on adiposity in peripubertal children is limited.

Purpose of the Study:

  • To investigate associations between prenatal and early-life lead exposure and adiposity indicators in peripubertal children.
  • To examine the relationship between maternal bone lead and childhood body composition.

Main Methods:

  • Maternal bone lead (patella) assessed postpartum as a proxy for fetal exposure.
  • Child blood lead levels measured annually from ages 1-4.
  • Multivariable linear regression analyzed associations with BMI z-score, waist circumference, skinfolds, and body fat percentage in 248 children (ages 8-16).

Main Results:

  • Maternal patella lead showed significant inverse associations with child BMI z-score, waist circumference, sum of skinfolds, and body fat percentage.
  • No significant associations were found between postnatal lead exposure and adiposity indicators.

Conclusions:

  • Prenatal lead exposure is inversely associated with body composition in Mexican children.
  • Early lead exposure may play a role in fetal programming of child growth.
  • Further research is needed to understand the biological mechanisms involved.
Abstract

Keywords:
AdiposityBMIBody fat percentageBone leadPregnancy

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