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[Azlocillin stability in solutions and the solid state].

V L Lapidus, V D Kartseva, G M Nikolaev

    Antibiotiki I Meditsinskaia Biotekhnologiia = Antibiotics and Medical Biotechnology
    |December 1, 1987
    PubMed
    Summary
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    Azlocillin stability is highest in aqueous solutions around pH 6.0 and remains stable in its solid form under various environmental conditions, including exposure to light and different gases.

    Area of Science:

    • Pharmaceutical Chemistry
    • Physical Chemistry
    • Drug Stability Studies

    Background:

    • Azlocillin is a crucial antibiotic requiring defined storage conditions.
    • Understanding azlocillin's degradation pathways is vital for maintaining its efficacy.
    • Environmental factors can significantly impact antibiotic stability.

    Purpose of the Study:

    • To determine the stability profile of azlocillin in aqueous solutions across a wide pH range.
    • To investigate the kinetics of azlocillin degradation.
    • To assess the stability of solid-state azlocillin under various environmental stresses.

    Main Methods:

    • Aqueous solutions of azlocillin were prepared and subjected to varying pH (1.5-12.5) and temperatures.
    • Degradation kinetics were analyzed using first-order reaction principles.

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  • The Arrhenius equation was employed to describe temperature-dependent degradation.
  • Solid-state azlocillin was exposed to oxygen, carbon dioxide, and light.

    • Main Results:

    • Azlocillin degradation in solution follows an irreversible first-order reaction.
    • Optimal stability in aqueous solutions was observed at approximately pH 6.0.
    • The temperature dependence of degradation followed the Arrhenius equation.
    • Azlocillin powder demonstrated stability in solid state when exposed to oxygen, carbon dioxide, and light.

    Conclusions:

    • Azlocillin exhibits maximum stability in aqueous solutions near neutral pH (around 6.0).
    • The antibiotic is robust in its solid form, maintaining quality under common environmental exposures.
    • These findings are critical for formulating and storing azlocillin-based pharmaceuticals.