Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

8.1K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
8.1K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.7K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.6K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.6K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

4.1K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
4.1K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

6.5K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case Report: Upper extremity deep vein thrombosis revealing an occult invasive ductal breast carcinoma.

Frontiers in cardiovascular medicine·2026
Same author

PDMS biointerfaces featuring honeycomb-like well microtextures designed for a pro-healing environment.

RSC advances·2025
Same author

Macrophage Immunomodulation and Suppression of Bacterial Growth by Polydimethylsiloxane Surface-Interrupted Microlines' Topography Targeting Breast Implant Applications.

Polymers·2024
Same author

Surface pre-treatment of aluminum alloy for mechanical improvement of adhesive bonding by maple-assisted pulsed laser evaporation technique.

RSC advances·2024
Same author

Hybrid bio-nanoporous peptide loaded-polymer platforms with anticancer and antibacterial activities.

Nanoscale advances·2024
Same author

Surface Modification Using MAPLE Technique for Improving the Mechanical Performance of Adhesive Joints.

Nanomaterials (Basel, Switzerland)·2023

Related Experiment Video

Updated: Jan 22, 2026

Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue
07:38

Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue

Published on: October 18, 2018

9.3K

Lactoferrin in Bone Tissue Regeneration.

Madalina Icriverzi1,2, Valentina Dinca3, Magdalena Moisei1

  • 1Ligand-Receptor Interaction Department, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.

Current Medicinal Chemistry
|July 2, 2019
PubMed
Summary

Lactoferrin (Lf) promotes osteoblast activity and inhibits osteoclast formation, aiding bone regeneration. Nanotechnology enhances Lf delivery for treating bone diseases and injuries.

Keywords:
Lactoferrinbonenanoformulationsosteoblastosteoclastregeneration.

More Related Videos

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.0K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.3K

Related Experiment Videos

Last Updated: Jan 22, 2026

Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue
07:38

Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue

Published on: October 18, 2018

9.3K
Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.0K
Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

13.3K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cell Biology

Background:

  • Lactoferrin (Lf) exhibits diverse biological properties, with significant interest in its role in bone regeneration.
  • Lf influences osteoblast survival, proliferation, and differentiation, while inhibiting osteoclast-mediated bone resorption.

Purpose of the Study:

  • To review the current research on lactoferrin's involvement in bone growth and healing.
  • To explore the potential therapeutic applications of Lf in bone tissue regeneration and disease treatment.

Main Methods:

  • In vitro and in vivo studies investigating Lf's effects on bone cells.
  • Analysis of signaling pathways and gene expression related to Lf action.
  • Development of nanotechnology-based strategies to improve Lf bioavailability and efficacy.

Main Results:

  • Lf promotes osteoblast activity and survival through mitogenic effects and signaling pathway activation.
  • Lf effectively inhibits osteoclastogenesis, halting bone resorption.
  • Nanotechnology formulations (e.g., liposomes, nanofibers, implant coatings) enhance Lf's biological properties and in vivo bioavailability.

Conclusions:

  • Lactoferrin demonstrates significant potential as a therapeutic agent for bone regeneration and treating bone diseases.
  • Nanotechnology-based delivery systems are crucial for overcoming Lf's poor bioavailability and maximizing its therapeutic benefits.
  • Combinations of Lf with biomaterials like hydroxyapatite can further enhance efficacy in regulating bone homeostasis.