Circulating Factors and Ultrasono-findings are Linked to Previous Atherosclerotic Burden and Recurrent Risk

Area of Science:

• Cardiovascular Research
• Neurology
• Hematology

Background:

• Platelet activation and platelet-leukocyte interactions are key in atherosclerosis and cerebrovascular disease (CVD) pathophysiology, including ischemic stroke.
• Atherosclerosis involves platelet-leukocyte interactions crucial for thrombus formation and cerebrovascular disease (CVD).
• This study examines circulating factors and platelet-leukocyte aggregates in aged individuals with and without a history of CVD.

Purpose of the Study:

• To investigate the relationship between circulating factors, ultrasonographic characteristics, and CVD risk.
• To evaluate changes in circulating factors and platelet-leukocyte aggregates in participants with and without a history of CVD.
• To determine if circulating factor changes and ultrasonographic characteristics correlate with CVD risk and long-term outcomes.

Main Methods:

• Two hundred fifteen participants were divided into groups with and without a history of CVD.
• Correlations between ultrasonography-based morphological characteristics and circulating factor-based functional changes were analyzed.
• Levels of p-selectin, activated monocytes, and platelet-monocyte aggregates were assessed.

Main Results:

• No significant difference in p-selectin levels was observed between groups.
• Activated monocyte and platelet-monocyte aggregate levels were elevated in participants with a history of CVD.
• Circulating factors and ultrasonographic characteristics correlated in the CVD group but not in the control group.

Conclusions:

• Circulating blood factor levels differ between participants with and without a history of CVD.
• Atherosclerotic severity appears to be influenced by CVD history and disease progression.
• Circulating factor levels, atherosclerotic severity, and CVD history are important for managing CVD progression and outcomes.