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Updated: Jan 22, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
Microbial Bioconversion: A Regio-specific Method for Novel Drug Design and Toxicological Study of Metabolites
Maria Yousuf1, Waqas Jamil2, Khayala Mammadova3
1Dow College of Biotechnology, Department of Bioinformatics, Dow University of Health Sciences, Karachi, Pakistan.
Abstract:
The methods of chemical structural alteration of small organic molecules by using microbes (fungi, bacteria, yeast, etc.) are gaining tremendous attention to obtain structurally novel and therapeutically potential leads. The regiospecific mild environmental friendly reaction conditions with the ability of novel chemical structural modification in compounds categorize this technique; a distinguished and unique way to obtain medicinally important drugs and their in vivo mimic metabolites with costeffective and timely manner. This review article shortly addresses the immense pharmaceutical importance of microbial transformation methods in drug designing and development as well as the role of CYP450 enzymes in fungi to obtain in vivo drug metabolites for toxicological studies.
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