Serum cholesterol levels preceding to suicide death in Japanese workers: a nested case-control study
Sanmei Chen1, Tetsuya Mizoue1, Huanhuan Hu1
1Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan.
Objective:
To investigate the association between suicide death and serum cholesterol levels as measured at times close to suicide death.
Methods:
We conducted a nested case-control study of 41 cases of suicide deaths and 205 matched controls with serum total cholesterol (TC) levels till 3 years before suicide death in a large cohort of Japanese workers.
Results:
Individuals in the lowest versus highest tertile/predefined category of TC in a Japanese working population had a three- to four-fold greater risk of suicide death. Each 10 mg/dl decrement of average TC was associated with an 18% increased chance of suicide death (95% confidence interval, 2-35%). Similar results were found for TC levels at each year.
Conclusion:
These results suggest that a low serum TC level in recent past is associated with an increased risk of suicide death.
Related Concept Videos
Cholesterol: Significance and Regulation
Considering cholesterol and...
Serum Laboratory Studies, Stool Test, Breath Test
Serum Studies: Renal Function Tests
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
High-Level and Low-Level Awareness


