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Updated: Jan 22, 2026
08:15
Gastrointestinal Motility Monitor GIMM
Published on: December 1, 2010
31.5K
Changing patterns of upper gastrointestinal bleeding over 23 years in Turkey
Nilay Danış1, Fatih Tekin1, Ulus Salih Akarca1
1Department of Gastroenterology, Ege University School of Medicine, İzmir, Turkey.
Summary
The causes of nonvariceal upper gastrointestinal bleeding (NVUGB) shifted towards older patients and anticoagulant use over 23 years. While surgical interventions decreased, overall mortality remained stable.
Area of Science:
- Gastroenterology
- Internal Medicine
- Clinical Epidemiology
Background:
- Nonvariceal upper gastrointestinal bleeding (NVUGB) remains a significant clinical challenge.
- Understanding evolving trends in NVUGB is crucial for optimizing patient care.
Purpose of the Study:
- To compare the causes, demographics, risk factors, and outcomes of NVUGB patients over two distinct periods (1993-1995 vs. 2015-2016).
- To analyze changes in endoscopic hemostatic procedures and their impact.
Main Methods:
- Retrospective comparison of 421 patients (1993-1995) and 231 patients (2015-2016) with NVUGB.
- Analysis of epidemiological characteristics, risk factors, causes of bleeding, and treatment modalities.
Main Results:
- Significant increase in mean patient age and prevalence of comorbid conditions.
- Rise in direct-acting oral anticoagulant use preceding bleeding events.
- Shift from duodenal to gastric ulcers as primary causes of bleeding; decreased use of emergency surgical hemostasis.
- No significant change in overall bleeding-related mortality between the periods.
Conclusions:
- Evolving NVUGB landscape influenced by an aging population, increased anticoagulant use, and improved management of chronic duodenal ulcers.
- Reduced reliance on emergency surgery for peptic ulcer bleeding without altering mortality rates.
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