Related Experiment Video
Updated: Jan 10, 2026

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
[Effect of lipid-lowering activity of the natural original enzyme preparation in the experiment]
N N Klyueva1, I V Okunevich1, N S Parfenova1
1Institute of Experimental Medicine, Saint-Petersburg, Russia.
Abstract:
The experimental study in vivo was aimed at evaluation of hypolipidemic action of the original natural microbial enzyme preparation of cholesterol oxidase (CHO). In preliminary chronic experiments in rats, rabbits, dogs, low toxicity, good tolerability, and anti-atherosclerotic activity of the CHO preparation were established. To assess the effect of CHO under conditions of moderate, nutritional, atherogenic dyslipoproteinemia, experiments were carried out in rats, guinea pigs, and rabbits. It was shown that administration of CHO had the pronounced lipid-lowering effect in models of atherogenic dyslipoproteinemia induced in these animals.
Related Concept Videos
Enzyme Inhibition
Lipid-Lowering Drugs: Statins and Miscellaneous Agents

