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Vaccinations01:51

Vaccinations

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Cancer Vaccines01:30

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Updated: Jan 22, 2026

Plaquing of Herpes Simplex Viruses
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Shingrix: A New Herpes Zoster Vaccine.

Fraidy Maltz, Brooke Fidler

    P & T : a Peer-Reviewed Journal for Formulary Management
    |July 2, 2019
    PubMed
    Summary

    Shingrix is a new vaccine designed to prevent herpes zoster, commonly known as shingles. This vaccine offers a novel approach to managing and preventing this painful viral infection.

    Area of Science:

    • Immunology
    • Vaccinology
    • Virology

    Background:

    • Herpes zoster (shingles) is a reactivation of the varicella-zoster virus, causing a painful rash.
    • The incidence of herpes zoster increases with age, posing a significant public health concern.
    • Existing prevention strategies have limitations, highlighting the need for effective vaccines.

    Purpose of the Study:

    • To evaluate the efficacy and safety of Shingrix, a novel vaccine for the prevention of herpes zoster.
    • To assess the immunogenicity of Shingrix in target populations.
    • To determine the duration of protection offered by Shingrix.

    Main Methods:

    • Phase III clinical trials were conducted to assess vaccine efficacy.
    • Immunogenicity was measured by antibody titers and cell-mediated immune responses.

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  • Safety and reactogenicity were monitored throughout the study duration.

    • Main Results:

    • Shingrix demonstrated high vaccine efficacy in preventing herpes zoster across different age groups.
    • The vaccine elicited robust and sustained immune responses.
    • The safety profile of Shingrix was favorable, with manageable adverse events.

    Conclusions:

    • Shingrix is a highly effective vaccine for the prevention of herpes zoster.
    • The vaccine provides long-lasting protection and has an acceptable safety profile.
    • Shingrix represents a significant advancement in the prevention of shingles.